Cell Signaling Technology YAP, TAZ and TEAD Antibodies

Featured in the CST blog post:

"Something to YAP About! Progress in Targeting YAP/TAZ-TEAD Signaling in Cancer Research."

 

YAP and its paralog TAZ (WWTR1), often referred to collectively as YAP/TAZ, are transcriptional co-activators that play important roles in regulating tissue growth and organ size. YAP and TAZ function—largely independently and with differing expression patterns1—as key signaling molecules within what is often referred to as the Hippo signaling pathway.

CST has a variety of highly validated antibody targets for studying the YAP/TAZ-TEAD signaling pathway. All CST antibodies are validated in accordance with the CST Hallmarks of Antibody Validation, six complementary strategies used by our scientists to validate antibody target specificity, maximizing the likelihood of generating reproducible immunoassay data.

Validation of YAP and TAZ monoclonal antibodies in immunohistochemistry (IHC) is described in detail in the CST scientist-authored publication “YAP vs. TAZ: differences in expression revealed through rigorous validation of target-specific monoclonal antibodies," which received the 2020 Outstanding Publication Award by the Journal of Histotechnology.

Learn more insights in the blog post.