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Cell Signaling Arginase-1 (D4e3m) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)
Cell Signaling Arginase-1 (D4e3m) Xp Rabbit mAb (Alexa Fluor 488 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)
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$435.00
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$435.00
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NETA PART: | CSIG-66297S |
MFG.PART: | 66297S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µl (50 tests) |
Reactivity | H M R |
Sensitivity | Endogenous |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Immunofluorescence (Frozen): 1:100, Immunofluorescence (Immunocytochemistry): 1:100 - 1:200} |
Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. |
Specificity/Sensitivity | Arginase-1 (D4E3M™) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total arginase-1 protein. This antibody does not cross-react with arginase-2. |
Species Reactivity | Human, Mouse, Rat |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val47 of human arginase-1 protein. |
Background | L-arginine plays a critical role in regulating the immune system (1-3). In inflammation, cancer, and certain other pathological conditions, myeloid cell differentiation is inhibited leading to a heterogeneous population of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs). MDSCs are recruited to sites of cancer-associated inflammation and express high levels of arginase-1 (4). Arginase-1 catalyzes the final step of the urea cycle converting L-arginine to L-ornithine and urea (5). Thus, MDSCs increase the catabolism of L-arginine resulting in L-arginine depletion in the inflammatory microenvironment of cancer (4,6). The reduced availability of L-arginine suppresses T cell proliferation and function and thus contributes to tumor progression (4,6). Arginase-1 is of great interest to researchers looking for a therapeutic target to inhibit the function of MDSCs in the context of cancer immunotherapy (7). In addition, research studies have demonstrated that arginase-1 distinguishes primary hepatocellular carcinoma (HCC) from metastatic tumors in the liver, indicating its value as a potential biomarker in the diagnosis of HCC (8,9). |
SKU | CSIG-66297S |
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Supplier Part Number | 66297S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer Name | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | +4C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |