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Cayman Osu03012; Purity- Greater Than Or Equal To 98%; Size- 100
NETA PART: | CAYM-10008005-100 |
MFG.PART: | 10008005-100 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 μM), which is reversible upon importazole washout. Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells., It also induces defects in spindle and microtubule formation in vitro.
WARNING This product is not for human or veterinary use.
Technical Information
- IPZ
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
- Ethanol: 5 mg/ml
Shipping & Storage Information
SKU | CAYM-10008005-100 |
---|---|
Supplier Part Number | 10008005-100 |
UM | EA |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10008005m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 742112-33-0 |