Cayman Flavopiridol (Hydrochloride); Purity- Greater Than Or Equa

Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC₅₀s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively).¹ It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a K_i value of 3 nM.² Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC₅₀ = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC₅₀ = 7 nM), and HIV-1 replication in HEK239T cells (IC₅₀ = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model.¹ It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.³

WARNING This product is not for human or veterinary use.