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Cayman Flavopiridol (Hydrochloride); Purity- Greater Than Or Equa
NETA PART: | CAYM-10009197-50 |
MFG.PART: | 10009197-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Flavopiridol is an orally bioavailable inhibitor of cyclin dependent kinases (IC50s = ~100, ~100, ~100, and 300 nM for Cdk1, Cdk2, Cdk4, and Cdk7, respectively).1 It also inhibits TEFb, a complex composed of Cdk9 and cyclin T1, with a Ki value of 3 nM.2 Flavopiridol inhibits transcription of a CMV promoter in HeLa nuclear extract (IC50 = 34 nM), Tat-stimulated transcription of an HIV-1 promotor (IC50 = 7 nM), and HIV-1 replication in HEK239T cells (IC50 = <10 nM). In vivo, flavopiridol (5 mg/kg, i.p.) induces apoptosis and cyclin D1 depletion and delays tumor growth in an HN-12 head and neck carcinoma mouse xenograft model.1 It also suppresses synovial hyperplasia and joint destruction in a mouse model of collagen-induced arthritis.3
WARNING This product is not for human or veterinary use.
Technical Information
- Alvocidib
- HL 275
- HMR 1275
- L-
868,275
- DMF: 16 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 12.5 mg/ml
- Ethanol: 1.6 mg/ml
Shipping & Storage Information
SKU | CAYM-10009197-50 |
---|---|
Supplier Part Number | 10009197-50 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10009197m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 131740-09-5 |