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Cayman Srebp-2 Blocking Peptide; Size- 1 Ea
NETA PART: | CAYM-10009266-1 |
MFG.PART: | 10009266-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Betrixaban is an inhibitor of the serine protease Factor Xa (Ki = 0.117 nM; IC50 = 1.5 nM), the enzyme that activates prothrombin in the blood coagulation cascade. It is selective for Factor Xa over hERG channels (Ki = 1.8 µM; IC50 = 8.9 µM), indicating a low potential for adverse cardiac effects. In vitro, betrixaban inhibits thrombin generation when used at concentrations ranging from 5 to 25 ng/mL in a tissue factor-induced thrombin generation assay. In vivo, it inhibits thrombus mass formation by 76% in a rabbit clot accretion model when used at a dose of 3 mg/kg. Formulations containing betrixaban have been used as anticoagulants in the treatment and prevention of venous thromboembolism.
WARNING This product is not for human or veterinary use.
Technical Information
- MK-4448
- MLN1021
- PRT054021
- DMF: 2 mg/ml
- DMSO: 2 mg/ml
- DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
Shipping & Storage Information
SKU | CAYM-10009266-1 |
---|---|
Supplier Part Number | 10009266-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10009266m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |