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Cayman Capsaicin (Technical Grade); Purity- Greater Than Or Equal
NETA PART: | CAYM-10010743-500 |
MFG.PART: | 10010743-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities.,,, It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1; EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619. Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2; Item No. ) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages. Capsaicin induces substance P (Item No. ) release in rat spinal cord slices with an EC50 value of 2.3 µM. It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.). Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 50 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 50 mg/ml
- PBS (pH 7.2): 0.1 mg/ml
Shipping & Storage Information
SKU | CAYM-10010743-500 |
---|---|
Supplier Part Number | 10010743-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10010743m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 404-86-4 |