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Cayman Terbinafine (Hydrochloride); Purity- Greater Than Or Equal
NETA PART: | CAYM-10011619-500 |
MFG.PART: | 10011619-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
LOXO-292 is an inhibitor of the receptor tyrosine kinase RET. It inhibits the phosphorylation of a KIF5B-RET fusion protein expressed in HEK293 cells (IC50 = 4 nM). LOXO-292 selectively inhibits proliferation of cancer cells containing RET mutations or gene fusions, including RETM918T-containing MZ-CRC-1 medullary thyroid and CCDC6-RET gene fusion-positive TPC-1 thyroid cancer cells, by 20 to 1,700-fold. It improves survival in a CCDC6-RET gene fusion-positive orthotopic patient-derived xenograft (PDX) mouse model of brain cancer when administered at a dose of 30 mg/kg. Formulations containing LOXO-292 have been used in the treatment of RET mutation- or gene fusion-positive lung or thyroid cancers.
WARNING This product is not for human or veterinary use.
Technical Information
- ARRY-192
- Selpercatinib
- DMF: 1 mg/ml
- DMSO: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-10011619-500 |
---|---|
Supplier Part Number | 10011619-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10011619m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 78628-80-5 |