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Cayman Tyrosine Hydroxylase Polyclonal Antibody; Size- 1 Ea
NETA PART: | CAYM-10604-1 |
MFG.PART: | 10604-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
PRLX-93936 is an analog of erastin (Item No. ) that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM. PRLX-93936 inhibits tumor growth in PANC-1 and HT-1080 xenograft models when administered at a dose of 50 mg/kg and induces tumor regression when administered at a dose of 100 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: Soluble
Shipping & Storage Information
SKU | CAYM-10604-1 |
---|---|
Supplier Part Number | 10604-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/10604m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |