Cayman Utx (Human, Recombinant); Purity- Greater Than Or Equal To

Ubiquitously transcribed tetratricopeptide repeat X (UTX) gene codes for the widely-expressed UTX protein. The UTX gene is localized on the X chromosome and is a homolog of the ubiquitously transcribed mouse Y chromosome (UTY) gene. UTX gene expression has been shown to evade X-chromosome inactivation. The JmjC-containing UTX protein is a member of the hydroxylase family of enzymes, which are α-ketoglutarate-dependent Fe (II) oxygenases. UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3. UTX works in opposition to the polycomb repressive complex 2 (PRC2) group protein EZH2, playing a role in cancers with abberant H3K27 methylation.

WARNING This product is not for human or veterinary use.