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Cayman Gsk1059615; Purity- Greater Than Or Equal To 98%; Size- 10
Cayman Gsk1059615; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$111.00
Your Price
$111.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-11569-10 |
| MFG.PART: | 11569-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
PI 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation. Its signaling pathway is the most commonly mutated pathway in human cancers. GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM) and the common activating mutants of p110α (E542K, E545K, and H1047R) found in cancer., It prevents proliferation in BT474 tumor xenografts and reduces MAPK signaling following twice daily dosing at 25 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5Z-[[4-(4-
CAS Number
958852-01-2
Molecular Formula
C18H11N3O2S
Formula Weight
333.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2.5 mg/ml
- DMSO: 3 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
295, 347 nm
SMILES
O=C(NC/1=O)SC1=C/C2=CC(C(C3=CC=NC=C3)=CC=N4)=C4C=C2
InChi Code
InChI=1S/C18H11N3O2S/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12/h1-10H,(H,21,22,23)/b16-10-
InChi Key
QDITZBLZQQZVEE-YBEGLDIGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11569-10 |
|---|---|
| Supplier Part Number | 11569-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/11569m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 958852-01-2 |