Cayman Necrostatin-1; Purity- Greater Than Or Equal To 98%; Size-

BAY-545 is an adenosine A_2B receptor antagonist. It is selective for adenosine A_2B receptors over A₁, A_2A, and A₃ receptors with IC₅₀ values of 66, 1,300, 820, and >6,700 nM, respectively, in CHO cell membranes expressing human recombinant receptors. BAY-545 reduces increases in the levels of IL-6 induced by the adenosine receptor agonist 5-(N-ethylcarbamoyl)adenosine (NECA; Item No. ) in LL29 fibroblast cells (IC₅₀ = 185 nM). It decreases FITC-induced increases in the levels of IL-6 in lung homogenates and cell numbers in bronchoalveolar lavage fluid (BALF) and reduces silica-induced increases in the levels of TGF-β1 in lung homogenates, but not cell numbers in BALF, in mouse models of pulmonary fibrosis when administered at a dose of 500 mg/kg.

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