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Cayman 3-Acetyl-11-Keto- Betaboswellic Acid; Purity- Greater Th
NETA PART: | CAYM-11672-10 |
MFG.PART: | 11672-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
BIBX1382 is an EGFR inhibitor (IC50 = 3 nM). It is selective for EGFR over HER2 (IC50 = 3,400 nM), as well as insulin-like growth factor 1 receptor (IGF-1R), β-insulin receptor kinase (β-InsRK), c-Met, c-Src, and VEGFR2 (IC50s = >10 µM for all). BIBX1382 inhibits proliferation and colony formation in A549 cancer cells expressing mutant K-Ras, as well as FaDu cancer cells expressing wild-type K-Ras when used at a concentration of 5 µM. It enhances radiation-induced cytotoxicity in mutant K-Ras-expressing A549 and MDA-MB-231 cancer cells, but not FaDu, HTB-35, or HH4dd cancer cells that express wild-type K-Ras. BIBX1382 reduces tumor growth in A431 and FaDu mouse xenograft models when administered at doses of 70 and 60 mg/kg per day, respectively.
WARNING This product is not for human or veterinary use.
Technical Information
- BIBX 1382 BS
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
Shipping & Storage Information
SKU | CAYM-11672-10 |
---|---|
Supplier Part Number | 11672-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11672m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 67416-61-9 |