We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Andrographolide; Purity- Greater Than Or Equal To 98%; Siz
NETA PART: | CAYM-11679-500 |
MFG.PART: | 11679-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
GW 9508 is a small-molecule agonist of GPR40/FFA1 (EC50 = 47.8 nM for calcium mobilization in HEK293 cells). It is selective for GPR40/FFA1 over GPR120/FFA4 (EC50 = 3,467 nM), as well as GPR43/FFA2 and GPR41/FFA3 (EC50s = >50 µM). GW 9508 potentiates glucose-stimulated and potassium chloride-mediated insulin secretion in MIN6 pancreatic β-cells but does not affect glucose-stimulated insulin secretion in primary rat or mouse islet cells. It increases phosphorylation of AMP-activated protein kinase (AMPK) and acyl-CoA carboxylase (ACC), indicating AMPK and ACC activation, and decreases hepatic lipid accumulation in a mouse model of high-cholesterol diet-induced hepatic steatosis when administered at a dose of 100 mg/kg per day for three days.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 20 mg/ml
- DMSO: 15 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Methanol: 30 mg/ml
Shipping & Storage Information
SKU | CAYM-11679-500 |
---|---|
Supplier Part Number | 11679-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11679m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 5508-58-7 |