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Cayman Betulinic Acid; Purity- Greater Than Or Equal To 97%; Size
NETA PART: | CAYM-11686-500 |
MFG.PART: | 11686-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
BMH-21 is an inhibitor of RNA polymerase I. It binds to GC-rich sequences in DNA and ribosomal DNA (rDNA) and inhibits RNA polymerase I transcription in vitro. It inhibits expression of the 47S rRNA transcript (IC50 = 60 nM), disrupts the structure of the nucleolus, and leads to removal of the RNA polymerase complex from rDNA by inducing dissociation and destruction of RPA194 through a proteasome-dependent mechanism. BMH-21 also activates p53 in the nanomolar range. It reduces viability of several cancer cell lines but not of non-cancerous cells (IC50s = 0.7, 1.9, ≥40, and 2.7 µM for A375, human diploid fibroblasts, primary human melanocytes, and HIMEC cells, respectively). BMH-21 intercalates with DNA but does not induce DNA damage via the ataxia-telangiectasia mutated (ATM) kinase pathway. BMH-21 (25 mg/kg) inhibits tumor growth in melanoma and colon cancer mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 2 mg/ml
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml
- DMSO: 1 mg/ml
- Ethanol: 0.2 mg/ml
Shipping & Storage Information
SKU | CAYM-11686-500 |
---|---|
Supplier Part Number | 11686-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11686m.pdf |
Temperature | 4 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CA |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 472-15-1 |