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Cayman Purpurin; Purity- Greater Than Or Equal To 95%; Size- 25 G
NETA PART: | CAYM-11752-25 |
MFG.PART: | 11752-25 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK), also known as MAP3K12 (Ki = 500 pM). It also inhibits phosphorylated JNK (IC50 = 30 nM) and is highly selective for DLK over other MAP kinases (IC50 > 5,000 nM for MKK4 and MKK7), JNKs (IC50s = 129, 514, and 364 nM for JNK1, JNK2, and JNK3, respectively), and mixed-lineage kinases (MLKs; IC50s = 68, 767, and 602 nM for MLK1, MLK2, and MLK3, respectively). GNE-3511 protects primary neurons in an in vitro axon degeneration assay (IC50 = 107 nM). In an MPTP mouse model of Parkinson’s disease, a high dose of GNE-3511 (75 mg/kg) completely suppresses phosphorylated c-Jun (p-c-Jun) expression, while a low dose (37.5 mg/kg) moderately reduces its expression.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: 20 mg/ml
- Methanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-11752-25 |
---|---|
Supplier Part Number | 11752-25 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11752m.pdf |
Temperature | 22 |
Refrigerated-Frozen | Ambient |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 25 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 81-54-9 |