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Cayman 24 Alphaethyl Cholesterol; Purity- Greater Than Or Equal
Cayman 24 Alpha -Ethyl Cholesterol; Purity- Greater Than Or Equal To 70%; Size- 5 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$37.00
Your Price
$37.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CAYM-11756-5 |
MFG.PART: | 11756-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 µM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac (Item No. ), and rat primary β-cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[2-chloro-4-[ [4-(2-thienyl )-2-pyrimidin yl]amino]phen yl](4-methyl- 1-piperazinyl )-methanone
CAS Number
1139875-74-3
Molecular Formula
C20H20ClN5OS
Formula Weight
413.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: soluble
λmax
288 nm
SMILES
CN1CCN(C(C2=C(Cl)C=C(NC3=NC(C4=CC=CS4)=CC=N3)C=C2)=O)CC1
InChi Code
InChI=1S/C20H20ClN5OS/c1-25-8-10-26(11-9-25)19(27)15-5-4-14(13-16(15)21)23-20-22-7-6-17(24-20)18-3-2-12-28-18/h2-7,12-13H,8-11H2,1H3,(H,22,23,24)
InChi Key
CLDIUVXCUVQLGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
SKU | CAYM-11756-5 |
---|---|
Supplier Part Number | 11756-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11756m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 83-46-5 |