Cayman Tetrahydrocurcumin; Purity- Greater Than Or Equal To 95% (

Tetrahydrocurcumin is a metabolite of curcumin (Item Nos. | ) that has diverse biological activities, including antioxidant, anti-inflammatory, anti-angiogenic, and anticancer properties.^,,, It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. ) radicals in a cell-free assay with an EC₅₀ value of 16.8 μM. Tetrahydrocurcumin (50 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 expression in RAW 264.7 cells. It also inhibits LPS-induced increases in TNF-α release when used at a concentration of 100 µM and increases in nitric oxide (NO) production and IL-6 levels in a concentration-dependent manner. Tetrahydrocurcumin reduces carrageenan-induced paw edema in rats (ED₅₀ = 20 mg/kg). It also reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGF receptor 2 (VEGFR2), and hypoxia-inducible factor-1α (HIF-1α) expression in a CaSki cervical cancer nude mouse xenograft model when administered at doses of 100, 300, and 500 mg/kg.

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