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Cayman Mam2201 N-(3-Fluoropentyl) Isomer; Purity- Greater Than Or
NETA PART: | CAYM-11781-1 |
MFG.PART: | 11781-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
NSC 23925 is a non-substrate inhibitor of P-glycoprotein (P-gp). It selectively reverses multidrug resistance mediated by P-gp over resistance mediated by multidrug resistance-associated protein 1 (MRP1/ABCC1) or breast cancer resistance protein (BCRP/ABCG2). It resensitizes paclitaxel-resistant SKOV3TR and OVCAR-8TR cells to paclitaxel (Item No. ). NSC 23925 reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates, including calcein AM (Item No. ) in multidrug-resistant SKOV3TR and OVCAR-8TR cells. It prevents paclitaxel-induced overexpression of the P-gp gene MDR1 and P-gp protein level increases in OVCAR-8 cells. It also prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model when administered at a dose of 50 mg/kg per day in combination with paclitaxel.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: Soluble
Shipping & Storage Information
SKU | CAYM-11781-1 |
---|---|
Supplier Part Number | 11781-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/11781m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 1797983-61-9 |