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Cayman Artemisinin; Purity- Greater Than Or Equal To 98%; Size- 5
Cayman Artemisinin; Purity- Greater Than Or Equal To 98%; Size- 500 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$87.00
Your Price
$87.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-11816-500 |
| MFG.PART: | 11816-500 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Riociguat is a stimulator of soluble guanylate cyclase (sGC)., It stimulates recombinant sGC in a concentration-dependent manner in vitro by up to 73-fold when used at a concentration of 100 μM or by up to 112-fold when used in combination with the nitric oxide (NO) donor DEA NONOate (Item No. ). It has no effect on phosphodiesterases PDE1-9 and PDE11 when used at concentrations up to 3 μM. Riociguat (1 and 10 mg/kg) reduces pulmonary and systemic arterial pressure in a rabbit model of acute pulmonary arterial hypertension (PAH) induced by U-46619 (Item No. ). It also inhibits increases in right ventricular systolic pressure, right heart hypertrophy, and pulmonary artery muscularization in hypoxia-induced mouse and monocrotaline-injected rat models of chronic PAH when administered at a dose of 10 mg/kg. Formulations containing riociguat have been used in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH) and PAH.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
625115-55-1
Synonyms
- BAY 63-2521
Molecular Formula
C20H19FN8O2
Formula Weight
422.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
λmax
212, 323 nm
SMILES
FC1=C(CN2C(N=CC=C3)=C3C(C4=NC(N)=C(N(C)C(OC)=O)C(N)=N4)=N2)C=CC=C1
InChi Code
InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
InChi Key
WXXSNCNJFUAIDG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-11816-500 |
|---|---|
| Supplier Part Number | 11816-500 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/11816m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 500 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 63968-64-9 |