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Cayman Biotin-Nhs; Purity- Greater Than Or Equal To 95%; Size- 25
NETA PART: | CAYM-13315-250 |
MFG.PART: | 13315-250 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A. It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 µM and in patient-derived CRC cell lines when used at a concentration of 5 µM. 4SC-202 (5 µM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine (Item No. ) and MK-2206 (Item No. ). 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-13315-250 |
---|---|
Supplier Part Number | 13315-250 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13315m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 250 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 35013-72-0 |