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Cayman Biotin-Nhs; Purity- Greater Than Or Equal To 95%; Size- 50
NETA PART: | CAYM-13315-500 |
MFG.PART: | 13315-500 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
MLN120B is an inhibitor of IκB kinase β (IKKβ; IC50 = 45 nM). It is selective for IKKβ over a panel of 30 tyrosine and serine/threonine kinases (IC50s = >50 µM for all). MLN120B inhibits NF-κB activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. ) with an IC50 value of 2.8 µM in a reporter assay. It inhibits proliferation in a panel of six multiple myeloma cancer cell lines, including cell lines resistant to dexamethasone (Item No. ), melphalan (Item No. ), or doxorubicin (Item No. ), in a concentration-dependent manner. MLN120B (50 mg/kg) reduces serum levels of soluble human IL-6 receptor, a marker of INA-6 cell growth, in a SCID-hu mouse model of bone marrow-engrafted INA-6 multiple myeloma. It reduces paw swelling, as well as cartilage destruction and bone erosion in the inflamed joints, in a rat model of rheumatoid arthritis induced by complete Freunds adjuvant (CFA) with a median effective dose (MED) of 12 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml
Shipping & Storage Information
SKU | CAYM-13315-500 |
---|---|
Supplier Part Number | 13315-500 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13315m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 500 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 35013-72-0 |