Cayman Biotin-X-Nhs; Purity- Greater Than Or Equal To 95%; Size-

p38 MAPK is a serine/threonine protein kinase and member of the MAPK family with roles in the regulation of immune responses and embryonic development, as well as cell differentiation, metabolism, and survival.^, It exists as 4 isoforms, p38α, -β, -γ, and -δ, encoded by MAPK14, MAPK11, MAPK12, and MAPK13, respectively, in humans. p38α MAPK is ubiquitously expressed, with the highest levels of expression in the heart, skeletal muscle, and brain.^, It is activated via dual phosphorylation of threonine 180 (Thr¹⁸⁰) and tyrosine 182 (Tyr¹⁸²) by the MAP2K kinases MKK3 and MKK6 in response to LPS or the production of inflammatory cytokines and induces signaling through protein kinases, transcription factors, and transcriptional regulators, among others.^, Levels of activated p38α MAPK (p38α phospho-Thr¹⁸⁰/Tyr¹⁸²) are increased and positively correlated with apoptosis in DU145 and PC3 prostate cancer cells in response to cisplatin (Item No. ). p38α Phospho-Thr¹⁸⁰/Tyr¹⁸² levels are also increased in adult rat ventricular monocytes during stimulated ischemia. Caymans p38α MAPK (Phospho-Thr¹⁸⁰/Tyr¹⁸²) Rabbit Monoclonal Antibody (Clone RM243) can be used for immunohistochemistry (IHC) and Western blot (WB) applications. The antibody recognizes p38α MAPK (phospho-Thr¹⁸⁰/Tyr¹⁸²) at approximately 38 kDa from human samples.

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