Cayman Rivenprost; Purity- Greater Than Or Equal To 98%; Size- 1

Rivenprost is a prodrug of the active free acid form, an agonist of the PGE₂ receptor subtype EP₄.^, Rivenprost (tested as the free acid) is selective for the EP₄ receptor over the EP₃, EP₂, and EP₁ receptor subtypes (K_is = 0.7, 56, 620, and >10,000 nM, respectively). It enhances bone morphogenic protein-induced increases in alkaline phosphatase activity, a marker of osteoblastic differentiation, in primary mouse calvarial osteoblasts when used at a concentration of 100 nM. Rivenprost decreases LPS-induced increases in plasma TNF-α levels in rats in a dose-dependent manner. It decreases trabecular separation, as well as increases bone volume, in rats when administered at a dose of 10 µg/kg. Rivenprost (3 and 10 mg/kg) increases proximal tibiae biomechanical strength in ovariectomized rats.

WARNING This product is not for human or veterinary use.