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Cayman Wz811; Purity- Greater Than Or Equal To 95%; Size- 1 Mg
NETA PART: | CAYM-13639-1 |
MFG.PART: | 13639-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
c-Kit, also known as CD117, is a type III receptor tyrosine kinase involved in the proliferation, differentiation, and survival of hematopoietic cells., It is composed of an N-terminal extracellular domain containing five immunoglobulin-like (Ig-like) domains, short transmembrane and juxtamembrane domains, and a C-terminal intracellular region containing the kinase domain. It is expressed in hematopoietic stem and progenitor cells, as well as certain non-hematopoietic tissues. c-Kit is activated by the binding of its ligand, stem cell factor (SCF), to the extracellular region, which induces autophosphorylation and the recruitment of signaling molecules to the intracellular region. c-Kit signal transduction activates a variety of signaling pathways, including the PI3K/Akt, RAS/MAPK, and JAK/STAT pathways., Homozygous knockout of Kit, the gene encoding c-Kit, is embryonic lethal, with mice developing severe anemia in utero. KIT is considered a proto-oncogene and activating mutations have been associated with a variety of cancers., Cayman’s c-Kit/CD117 (C-Term) Rabbit Monoclonal Antibody (Clone RM359) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.
WARNING This product is not for human or veterinary use.
Technical Information
- Cluster of Differentiation 117
- v-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog
- Mast/Stem Cell Growth Factor Receptor Kit
- Proto-oncogene c-Kit
- SCFR
- (+) c-Kit
Shipping & Storage Information
SKU | CAYM-13639-1 |
---|---|
Supplier Part Number | 13639-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13639m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 55778-02-4 |