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Cayman Wz811; Purity- Greater Than Or Equal To 95%; Size- 10 Mg;
Cayman Wz811; Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$138.00
Your Price
$138.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13639-10 |
| MFG.PART: | 13639-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 value of 0.8 μM. It is selective for cyclin D1/Cdk4, demonstrating 7-fold and 28-fold weaker activity against cyclin E/Cdk2 and cyclin B/Cdk1, respectively, and little activity against calcium/calmodulin-dependent protein kinase II and protein kinase A. This compound has been shown to inhibit HCT116 and NCI-H460 tumor cell growth (IC50s < 3.0 μM) by blocking retinoblastoma protein phosphorylation and inducing G1 cell cycle arrest.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
CAS Number
546102-60-7
Synonyms
- Cyclin-dependent kinase 4 Inhibitor
Molecular Formula
C20H10BrN3O2
Formula Weight
404.2
Purity
≥90%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 0.25 mg/ml
λmax
236, 259, 271, 283, 318, 397 nm
SMILES
O=C1NC(C2=C1C(C(C=CC(Br)=C3)=C3N4)=C4C5=C2C6=C(C=CC=C6)N5)=O
InChi Code
InChI=1S/C20H10BrN3O2/c21-8-5-6-10-12(7-8)23-18-14(10)16-15(19(25)24-20(16)26)13-9-3-1-2-4-11(9)22-17(13)18/h1-7,22-23H,(H,24,25,26)
InChi Key
NMFKDDRQSNVETB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13639-10 |
|---|---|
| Supplier Part Number | 13639-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13639m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 55778-02-4 |