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Cayman Nvp-Aew541 (Hydrochloride); Purity- Greater Than Or Equal
NETA PART: | CAYM-13641-1 |
MFG.PART: | 13641-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R; IC50 = 0.15 µM in a cell-free assay). It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2; IC50s = 0.14, 0.6, 0.42, and 0.53 µM, respectively, in cell-free assays). NVP-AEW541 selectively inhibits the autophosphorylation of IGF-1R over InsR, EGFR, PDGFR, c-Kit, and Bcr-Abl in cells (IC50s = 0.086, 2.3, >10, >10, >5, and >10 µM, respectively). It reduces tumor volume in an NWT-21 murine fibrosarcoma model when administered at doses of 20, 30, or 50 mg/kg twice per day.
WARNING This product is not for human or veterinary use.
Technical Information
- Ethanol: 0.3 mg/ml
- PBS (pH 7.2): 2.5 mg/ml
Shipping & Storage Information
SKU | CAYM-13641-1 |
---|---|
Supplier Part Number | 13641-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13641m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 2320261-63-8 |