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Cayman Abt-869; Purity- Greater Than Or Equal To 98%; Size- 10 Mg
NETA PART: | CAYM-13653-10 |
MFG.PART: | 13653-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ABT-869 is a dual VEGFR and PDGFR family kinase inhibitor (IC50s = 0.003, 0.004, 0.004, 0.19, 0.066, 0.003, and 0.014 µM for VEGFR1, VEGFR2, FLT3, VEGFR3, PDGFRβ, CSF-1R, and KIT, respectively).1 It is selective for these kinases over other tyrosine kinases, including RET, FGFR, Src, EGFR, and c-Met (IC50s = 1.9, >12.5, >50, >50, and >50 µM, respectively), but also inhibits Tie2 (IC50 = 0.17 µM). ABT-869 inhibits the proliferation of HT-29 colon and MDA-MB-435 breast cancer, 9L glioma, and MV4-11 acute myeloid leukemia cells (IC50s = 1.3, 2.4, 0.27, and 0.004 µM, respectively). It induces apoptosis in MV4-11 cells (IC50 = 0.03 µM) and inhibits VEGF-induced uterine edema in mice (ED50 = 0.5 mg/kg).2,1 ABT-869 (1, 3, and 10 mg/kg) improves survival in a MOLM-13 leukemia mouse xenograft model.2
WARNING This product is not for human or veterinary use.
Technical Information
- Linifanib
- DMF: 20 mg/ml
- DMSO: 25 mg/ml
- DMSO:PBS (pH 7.2) (1:5): 0.2 mg/ml
Shipping & Storage Information
SKU | CAYM-13653-10 |
---|---|
Supplier Part Number | 13653-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13653m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 796967-16-3 |