We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman Iwr-1-Endo; Purity- Greater Than Or Equal To 98%; Size- 5
Cayman Iwr-1-Endo; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$67.00
Your Price
$67.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13659-5 |
| MFG.PART: | 13659-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
ETC-159 is a potent and orally bioavailable inhibitor of porcupine (PORCN; IC50s = 18.1 and 70 nM for mouse and Xenopus PORCN, respectively). It inhibits β-catenin reporter activity (IC50 = 2.9 nM) and reduces the interaction of Wnt with its carrier protein WLS via decreased Wnt palmitoleation in STF3A cells, an effect that is reversed by overexpression of recombinant PORCN. ETC-159 inhibits PA-1 teratocarcinoma colony formation in soft agar (IC50 = 35 nM). In vivo, ETC-159 (1-10 mg/kg) reduces tumor growth in a dose-dependent manner in mice carrying a mouse mammary tumor virus LTR-Wnt1 transgene and in A-1 and NCCIT teratocarcinoma mouse xenograft models. It also reduces growth and induces differentiation in colon adenocarcinoma mouse xenograft models that contain R-spondin (RSPO) translocations.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,2,3,6-tetra
CAS Number
1638250-96-0
Synonyms
- ETC-1922159
Molecular Formula
C19H17N7O3
Formula Weight
391.4
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 33 mg/ml
- DMSO: 33 mg/ml
- DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
270 nm
SMILES
O=C1N(C)C(C(N(CC(NC2=NN=C(C3=CC=CC=C3)C=C2)=O)C=N4)=C4N1C)=O
InChi Code
InChI=1S/C19H17N7O3/c1-24-17-16(18(28)25(2)19(24)29)26(11-20-17)10-15(27)21-14-9-8-13(22-23-14)12-6-4-3-5-7-12/h3-9,11H,10H2,1-2H3,(H,21,23,27)
InChi Key
QTRXIFVSTWXRJJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13659-5 |
|---|---|
| Supplier Part Number | 13659-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13659m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 1127442-82-3 |