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Cayman Ys-121; Purity- Greater Than Or Equal To 98%; Size- 10 Mg
Cayman Ys-121; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$420.00
Your Price
$420.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13665-10 |
| MFG.PART: | 13665-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM)1 and 5-LO (IC50 = 4.1 μM).2 It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy.3 YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[4-chloro-
CAS Number
916482-17-2
Molecular Formula
C20H26ClN3O2S
Formula Weight
408.0
Purity
≥98%
Formulation(Request formulation change)
A solution in methyl acetate
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
203, 246, 292 nm
SMILES
CC1=C(NC2=CC(Cl)=NC(SC(C(O)=O)CCCCCC)=N2)C=CC=C1C
InChi Code
InChI=1S/C20H26ClN3O2S/c1-4-5-6-7-11-16(19(25)26)27-20-23-17(21)12-18(24-20)22-15-10-8-9-13(2)14(15)3/h8-10,12,16H,4-7,11H2,1-3H3,(H,25,26)(H,22,23,24)
InChi Key
HVJBWTVMRIOTEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-13665-10 |
|---|---|
| Supplier Part Number | 13665-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13665m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 916482-17-2 |