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Cayman Zk118182 Isopropyl Ester; Purity- Greater Than Or Equal To
Cayman Zk118182 Isopropyl Ester; Purity- Greater Than Or Equal To 98%; Size- 500 Micrograms; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$925.00
Your Price
$925.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13673-500 |
| MFG.PART: | 13673-500 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Elevated intraocular pressure (IOP) is an important risk factor in developing glaucoma. Certain prostaglandins (PGs) such as PGF2α and PGD2, have been shown to reduce IOP. ZK 118182 is a PG analog that has potent DP-agonist activity (EC50 = 16.5 nM) and a high nanomolar affinity for the DP receptor (Ki = 74 nM).1 ZK 118182 isopropyl ester is a prodrug formulation of ZK 118182 designed to enhance corneal absorption. At 0.03 μg, ZK 118182 isopropyl ester has been shown to lower monkey and rabbit IOP 46% and 20%, respectively, two hours after dosing, demonstrating a much more potent effect compared to the free acid.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[[(2Z)-4-
CAS Number
154927-31-8
Molecular Formula
C23H37ClO5
Formula Weight
429.0
Purity
≥98%
Formulation(Request formulation change)
A solution in methyl acetate
Solubility(Learn about Variance in Solubility)
- DMF: 3 mg/ml
- DMSO: 2 mg/ml
- Ethanol: 12.5 mg/ml
- Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
SMILES
Cl[C@H]1[C@H](C/C=C\COCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)C2CCCCC2)[C@H](O)C1
InChi Code
InChI=1S/C23H37ClO5/c1-16(2)29-23(27)15-28-13-7-6-10-18-19(22(26)14-20(18)24)11-12-21(25)17-8-4-3-5-9-17/h6-7,11-12,16-22,25-26H,3-5,8-10,13-15H2,1-2H3/b7-6-,12-11+/t18-,19-,20-,21-,22-/m1/s1
InChi Key
QLJUNFBXIBNQOL-LMJZMJOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 1 year
| SKU | CAYM-13673-500 |
|---|---|
| Supplier Part Number | 13673-500 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13673m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 500 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | Y |
| CAS Number | 154927-31-8 |