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Cayman Hdac-In-7; Purity- Greater Than Or Equal To 98%; Size- 1 M
NETA PART: | CAYM-13686-1 |
MFG.PART: | 13686-1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 µM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 µM). It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 µM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 µM). In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
- CS 055
- HBI 8000
- Tucidinostat
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
Shipping & Storage Information
SKU | CAYM-13686-1 |
---|---|
Supplier Part Number | 13686-1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/13686m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1616493-44-7 |