Cayman Hdac-In-7; Purity- Greater Than Or Equal To 98%; Size- 10

Chidamide is an inhibitor of histone deacetylases (HDACs; IC₅₀s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively).¹ It is selective for these HDACs over HDAC4-7 and 9 (IC₅₀s = >30 µM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC₅₀ = 2.1 µM).² It inhibits cell growth in a panel of 18 cancer cell lines (GI₅₀s = 0.4-40 µM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI₅₀s = >100 µM).¹ In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.¹

WARNING This product is not for human or veterinary use.