We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cayman 6-It; Purity- Greater Than Or Equal To 98%; Size- 10 Mg
Cayman 6-It; Purity- Greater Than Or Equal To 98%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$477.00
Your Price
$477.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-13938-10 |
| MFG.PART: | 13938-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
TAS 103 is an inhibitor of DNA topoisomerase I and II (IC50s = 2 and 6.5 µM, respectively). It stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells when used at a concentration of 3 µM. It is cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively). TAS 103 (15, 26, and 45 mg/kg per day) reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis. It also reduces tumor growth in a variety of human cancer mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[[2-
CAS Number
174634-09-4
Molecular Formula
C20H19N3O2 • 2HCl
Formula Weight
406.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- PBS (pH 7.2): 1 mg/ml
λmax
229, 244, 262, 292 nm
SMILES
O=C1C(C(NCCN(C)C)=NC2=C3C=CC(O)=C2)=C3C4=C1C=CC=C4.Cl.Cl
InChi Code
InChI=1S/C20H19N3O2.2ClH/c1-23(2)10-9-21-20-18-17(13-5-3-4-6-14(13)19(18)25)15-8-7-12(24)11-16(15)22-20;;/h3-8,11,24H,9-10H2,1-2H3,(H,21,22);2*1H
InChi Key
HAYAYGFVSIWSGQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13938-10 |
|---|---|
| Supplier Part Number | 13938-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/13938m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 21005-63-0 |