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Cayman Aaf-Cmk (Trifluoroacetate Salt); Purity- Greater Than Or E
Cayman Aaf-Cmk (Trifluoroacetate Salt); Purity- Greater Than Or Equal To 95%; Size- 10 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$115.00
Your Price
$115.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-14461-10 |
| MFG.PART: | 14461-10 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
PF-4693627 is an orally bioavailable inhibitor of microsomal prostaglandin E (PGE) synthase-1 (mPGES-1; IC50 = 3 nM). It is selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values greater than 50 μM, as well as COX-2 in fetal fibroblasts (IC50 = >10 μM). PF-4693627 inhibits LPS-stimulated synthesis of PGE2 in human whole blood (IC50 = 109 nM). In vivo, PF-4693627 (10 mg/kg) inhibits PGE2 production in a guinea pig model of carrageenan-induced air pouch inflammation.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[5-chloro-6-
CAS Number
1312815-93-2
Molecular Formula
C26H29Cl2N3O3
Formula Weight
502.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
- Ethanol: 5 mg/ml
λmax
300 nm
SMILES
ClC1=CC=C(C2=CC(OC(N3CCC(C(N[C@@H]4C[C@@H](CO)CCC4)=O)CC3)=N5)=C5C=C2Cl)C=C1
InChi Code
InChI=1S/C26H29Cl2N3O3/c27-19-6-4-17(5-7-19)21-13-24-23(14-22(21)28)30-26(34-24)31-10-8-18(9-11-31)25(33)29-20-3-1-2-16(12-20)15-32/h4-7,13-14,16,18,20,32H,1-3,8-12,15H2,(H,29,33)/t16-,20-/m0/s1
InChi Key
CPDNPVKDQXLYHO-JXFKEZNVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-14461-10 |
|---|---|
| Supplier Part Number | 14461-10 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/14461m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 10 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 184901-82-4 |