Cayman Ly341495; Purity- Greater Than Or Equal To 98%; Size- 10 M

Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC₅₀ = 10-50 nM), both isoforms of PP2A (IC₅₀ = 0.5 nM) and PP3 (IC₅₀ = 4 nM).^,, It is a very weak inhibitor of PP2B (IC₅₀ > 2 μM) and does not inhibit PP2C or other phosphatases.^, Presumably through these actions, okadaic acid is a potent carcinogen and induces tau phosphorylation.^, In sponge, okadaic acid plays a role in defense, inducing apoptosis in symbiotic or parasitic annelids.

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