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Cayman Pf-573228; Purity- Greater Than Or Equal To 95%; Size- 5 M
NETA PART: | CAYM-14924-5 |
MFG.PART: | 14924-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
CEP-40783 is an inhibitor of the receptor tyrosine kinases Axl and c-MET (IC50s = 7 and 12 nM, respectively). It inhibits Axl in 293GT cells expressing Axl and c-MET in NCI H1299 non-small cell lung cancer (NSCLC) cells with IC50 values of 0.26 and 6 nM, respectively. It also inhibits the receptor tyrosine kinases TYRO3 and MER (IC50s = 3.5 and 1.89 nM, respectively). CEP-40783 (0.3 mg/kg) induces complete regression of tumors in an Axl/NIH3T3 mouse xenograft model and reduces the metastatic tumor burden in mouse orthotopic breast cancer models. It also induces tumor stasis and regression in an EBC-1 NSCLC mouse xenograft model when administered at doses of 3 and 10 mg/kg, respectively. CEP-40783 reduces tumor growth in an MC38 mouse syngeneic model concomitantly with an increase in leukocyte infiltration into tumors, the production of IFN-γ in natural killer cells, and the percentage of CD8+ T cells in tumor tissue.
WARNING This product is not for human or veterinary use.
Technical Information
- RXDX-106
- DMF: 20 mg/ml
- DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml
- DMSO: 5 mg/ml
- Ethanol: 2 mg/ml
Shipping & Storage Information
SKU | CAYM-14924-5 |
---|---|
Supplier Part Number | 14924-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/14924m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | CN |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 869288-64-2 |