We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Glyburide (Potassium Salt); Purity- Greater Than Or Equal
NETA PART: | CAYM-15009-5 |
MFG.PART: | 15009-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
COG133 is a peptide fragment of ApoE that corresponds to residues 133-149 of the ApoE LDL receptor-binding domain and an antagonist of α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 720 nM)., It suppresses TNF-α and nitric oxide (NO) release in BV-2 microglia when used at concentrations ranging from 10 to 50 µM. In vivo, COG133 reduces LPS-induced increases in brain levels of TNF-α and IL-6 in mice. It decreases hippocampal neuronal degeneration and the latency to find the platform in the Morris water maze in a mouse model of closed head injury induced by surgical midline impact when administered at doses of 203 and 406 µg/kg. COG133 (1 mg/kg) also delays disease onset and reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).
WARNING This product is not for human or veterinary use.
Technical Information
- Ac-LRVRLASHLRKLRKRLL-NH2
- ApoE (133-149)
- DMSO: 1 mg/ml
- PBS (pH 7.2): 1 mg/ml
Shipping & Storage Information
SKU | CAYM-15009-5 |
---|---|
Supplier Part Number | 15009-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/15009m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 52169-36-5 |