Cayman Torcetrapib; Purity- Greater Than Or Equal To 98%; Size- 1

ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC₅₀s = 7.2 and 8.2 µM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects.^,,, ACPT-I (1-200 µM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED₅₀s = 0.08-49.3 nM, i.c.v.).^, ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 (Item No. ) and flumazenil (Item No. ), indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT_1A and GABA_A receptor.

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