Cayman Glp-1 (7-36) Amide (Trifluoroacetate Salt); Size- 1 Mg

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD₁ and PLD₂, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. CAY10594 is a potent PLD₂ inhibitor, both in vitro (IC₅₀ = 140 nM) and in cells (IC₅₀ = 110 nM). It is also effective as a PLD₁ inhibitor at higher concentrations (IC₅₀ = 5.1 μM in vitro, 1.0 μM in cells). CAY10594 strongly inhibits the invasive migration of breast cancer cells in transwell assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.

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