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Cayman Fubimina; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
NETA PART: | CAYM-15202-5 |
MFG.PART: | 15202-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
ARRY-520 is a potent inhibitor of the kinesin spindle protein Eg5 (IC50 = 6 nM). It is selective for Eg5 over a panel of 8 kinesins (IC50s = >100 μM) and a panel of 224 kinases at a concentration of 10 μM. ARRY-520 induces time-and dose-dependent cell death in HL-60, Jurkat, OCI-AML3, U937, and MOLM-13 leukemic cells. Downregulation of Eg5 expression sensitizes HL-60 cells to ARRY-520 (IC50s = 11.3 and 2 nM for wild-type and Eg5 knockdown HL-60 cells, respectively). ARRY-520 induces cell cycle arrest at the G2/M phase in a p53- and XIAP-independent manner in OCI-AML3 cells. It also inhibits blast colony formation of bone marrow samples derived from human acute myeloid leukemia (AML) patients. In vivo, ARRY-520 (20 mg/kg per day) completely eliminates tumors in the RPMI-8226 multiple myeloma and HL-60 and MV4-11 AML mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
- Filanesib
- DMF: 20 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 20 mg/ml
- PBS (pH 7.2): 0.2 mg/ml
Shipping & Storage Information
SKU | CAYM-15202-5 |
---|---|
Supplier Part Number | 15202-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/15202m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1984789-90-3 |