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Cayman Trametinib; Purity- Greater Than Or Equal To 95%; Size- 50
NETA PART: | CAYM-16292-50 |
MFG.PART: | 16292-50 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s = 2.2-174 nM) but does not inhibit the growth of wild-type COLO 320DM cells expressing both B-RAF and K-Ras (IC50 = >10,000 nM). It reduces tumor growth in HT-29 and COLO 205 mouse xenograft models when used at doses of 0.3 and 1 mg/kg per day. Trametinib (0.03 and 0.1 mg/kg per day) also decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis. Formulations containing trametinib, in combination with dabrafenib, have been used in the treatment of metastatic mutant B-RAFV600E melanoma.
WARNING This product is not for human or veterinary use.
Technical Information
- GSK1120212
- JTP-74057
- DMF: 2 mg/ml
- DMSO: 3 mg/ml
- DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
Shipping & Storage Information
SKU | CAYM-16292-50 |
---|---|
Supplier Part Number | 16292-50 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/16292m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 50 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 871700-17-3 |