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Cayman Azidoindolene 1; Purity- Greater Than Or Equal To 98%; Siz
NETA PART: | CAYM-17083-5 |
MFG.PART: | 17083-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
T2AA is an inhibitor of proliferating cell nuclear antigen (PCNA). It inhibits protein-protein interactions between PCNA and a PIP-box-containing peptide (IC50 = 1 μM) and full-length p21 as well as reduces cellular colocalization of PCNA and DNA polymerase δ. T2AA inhibits DNA replication and cell growth in U2OS and HeLa cells in a concentration-dependent manner and induces cell cycle arrest at the S phase when used at a concentration of 20 μM. It also increases DNA double strand break formation induced by cisplatin (Item No. ) in a neutral comet assay and cisplatin-induced inhibition of clonogenic survival in HeLa and U2OS cells.
WARNING This product is not for human or veterinary use.
Technical Information
- T2-amino Alcohol
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:8): 0.11
Shipping & Storage Information
SKU | CAYM-17083-5 |
---|---|
Supplier Part Number | 17083-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/17083m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 1364933-69-6 |