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Cayman Snx-2112; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
Cayman Snx-2112; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$268.00
Your Price
$268.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-22359-5 |
| MFG.PART: | 22359-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
SNX-2112 is a potent inhibitor of heat shock protein 90 (Hsp90) with a Kd value of 30 nM.1 In vitro, SNX-2112 induces down-regulation of the client proteins HER2 and Akt. It inhibits proliferation in a panel of cancer cell lines (IC50s = 10-50 nM). SNX-2112 (150 mg/kg) completely inhibits tumor growth in a BT474 breast cancer mouse xenograft model. SNX-2112 is also the active metabolite of prodrug SNX-5542 and preferentially accumulates in tumor tissue of mice treated with a single oral dose of 75 mg/kg SNX-5542. Formulations containing SNX-2112 are under clinical investigation for treatment of refractory solid tumors.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[(trans-4-
CAS Number
908112-43-6
Synonyms
- PF-04928473
Molecular Formula
C23H27F3N4O3
Formula Weight
464.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.25 mg/ml
- DMSO: 1 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
251, 360 nm
SMILES
NC(C1=CC=C(N2N=C(C(F)(F)F)C3=C2CC(C)(C)CC3=O)C=C1N[C@@H]4CC[C@@H](O)CC4)=O
InChi Code
InChI=1S/C23H27F3N4O3/c1-22(2)10-17-19(18(32)11-22)20(23(24,25)26)29-30(17)13-5-8-15(21(27)33)16(9-13)28-12-3-6-14(31)7-4-12/h5,8-9,12,14,28,31H,3-4,6-7,10-11H2,1-2H3,(H2,27,33)/t12-,14-
InChi Key
ZFVRYNYOPQZKDG-MQMHXKEQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22359-5 |
|---|---|
| Supplier Part Number | 22359-5 |
| UM | UNIT |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/22359m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 908112-43-6 |