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Cayman Skf 82958 (Hydrobromide)
Cayman Skf 82958 (Hydrobromide) - CAYM (Additional S&H Or Hazmat Fees May Apply)
List Price
$121.00
Your Price
$121.00
HOW MUCH YOU SAVE:
0.00 %
| NETA PART: | CAYM-29033-5 |
| MFG.PART: | 29033-5 |
| UNSPSC: | 12352200 |
| Manufacturer: | Cayman |
Product Description
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F). Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma. XL019 is a potent, bioavailable JAK inhibitor with preference for JAK2 (IC50 = 2 nM) over JAK1 and JAK3 (IC50s = 130 and 250 nM, respectively)., It is effective against JAK2V617F as well as JAK2 and inhibits phosphorylation of STAT5 in vivo.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-N-[4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]phenyl]-2-pyrrolidinecarboxamide
CAS Number
945755-56-6
Molecular Formula
C25H28N6O2
Formula Weight
444.5
Purity
≥90%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/ml
- DMSO: 10 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
300 nm
SMILES
O=C([C@H]1NCCC1)NC(C=C2)=CC=C2C3=CC=NC(NC(C=C4)=CC=C4N5CCOCC5)=N3
InChi Code
InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1
InChi Key
ISOCDPQFIXDIMS-QHCPKHFHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-29033-5 |
|---|---|
| Supplier Part Number | 29033-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | https://www.caymanchem.com/msdss/29033m.pdf |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | US |
| ProductLine | CAYM |
| Qty | 5 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 2 Business Days |
| Hazardous | N |
| CAS Number | 74115-01-8 |