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Cayman (В±)14-Hdha; Purity- Greater Than Or Equal To 98%; Size- 1
NETA PART: | CAYM-33550-0.1 |
MFG.PART: | 33550-0.1 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
PKI-166 is an ATP-competitive inhibitor of the EGF receptor (EGFR; IC50 = 0.0007 µM for the intracellular kinase domain). It is selective for the EGFR intracellular kinase domain over the serine/threonine kinases PKCα and Cdc2/cyclin B (IC50s = >100 and 78 µM, respectively), as well as FLK, c-Met, and Tek (IC50 = >1 µM for all), but does inhibit c-Src, c-Abl, VEGFR2/KDR, FLT1, and c-Kit (IC50s = 0.103, 0.028, 0.327, 0.962, and 2.21 µM, respectively). PKI-166 prevents phosphorylation of EGFR induced by EGF in L3.6pl pancreatic cancer cells in a concentration-dependent manner. It enhances the cytotoxicity of gemcitabine (Item No. ) in L3.6pl cells and reduces tumor growth and metastasis and increases survival in an L3.6pl mouse xenograft model when administered alone at a dose of 100 mg/kg per day with additive effects on these parameters when administered in combination with gemcitabine. PKI-166 also reduces tumor growth and inhibits angiogenesis in an SN12-PM6 human renal cell carcinoma mouse orthotopic model.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
Shipping & Storage Information
SKU | CAYM-33550-0.1 |
---|---|
Supplier Part Number | 33550-0.1 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/33550m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | Y |
CAS Number | 87042-40-8 |