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Cayman Ur-144 N-(5-Methylhexyl) Analog; Purity- Greater Than Or E
NETA PART: | CAYM-9001439-5 |
MFG.PART: | 9001439-5 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
NQ301 is a naphthoquinone with diverse biological activities, including antiplatelet, antithrombotic, anti-inflammatory, and antimicrobial properties.,,, It inhibits rabbit platelet aggregation induced by the thromboxane A2 receptor agonist U-46619 (Item No. ) in vitro (IC50 = 0.58 μM) and inhibits the conversion of arachidonic acid to thromboxane B2 in rabbit platelets in a concentration-dependent manner. It also inhibits human platelet aggregation induced by ADP, collagen, epinephrine, and the calcium ionophore A23187 in vitro (IC50s = 3.21, 15.69, 8.44, and 44.2 μM, respectively). NQ301 (50 and 100 mg/kg) increases tail bleeding time and exhibits a protective effect against pulmonary thrombosis in mice. It inhibits the protein tyrosine phosphatase CD45 with an IC50 value of 0.29 μM. NQ301 (3 mg/kg) inhibits ovalbumin-induced footpad swelling in a mouse model of delayed-type hypersensitivity. It is also active against C. albicans, A. niger, B. subtilis, S. aureus, E. coli, and P. aeruginosa (MICs = 12.5-50 μg/ml).
WARNING This product is not for human or veterinary use.
Technical Information
- DMF: 16 mg/ml
- DMSO: 14 mg/ml
- Ethanol: 2 mg/ml
Shipping & Storage Information
SKU | CAYM-9001439-5 |
---|---|
Supplier Part Number | 9001439-5 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9001439m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 5 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |