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Cayman Benocyclidine-D10; Purity- Greater Than Or Equal To 99% De
NETA PART: | CAYM-9001493-10 |
MFG.PART: | 9001493-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
N-(n-Butyl)deoxygalactonojirimycin (NB-DGJ) is an inhibitor of the glycolipid biosynthesis enzyme glucosylceramide synthase and the glycolipid catabolic enzymes glucocerebrosidase (GBA) and β-glucosidase 2 (GBA2).,,,, It also inhibits acid α-glucosidase, sucrase, maltase, and lactase. NB-DGJ (0.5-500 µM) reduces glycolipid levels in HL-60 and WEHI-3B cells. It decreases brain ganglioside levels in a Glb1-/- neonatal mouse model of GM1 gangliosidosis when administered intraperitoneally at doses of 600 and 1,200 mg/kg four times per day for three days. NB-DGJ (1-1,200 mg/kg per day for 35 days) increases testicular glucosylceramide levels in mice. NB-DGJ induces abnormal spermatid and acrosome formation, as well as reduces motility, in isolated mouse epididymal sperm when administered at doses of 15, 25, and 50 mg/kg per day. It also induces infertility, an effect that is reversed by withdrawal, in the same model.
WARNING This product is not for human or veterinary use.
Technical Information
- Lucerastat
- NBDGJ
- DMF: 20 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 5 mg/mL
- PBS (pH 7.2): 10 mg/mL
Shipping & Storage Information
SKU | CAYM-9001493-10 |
---|---|
Supplier Part Number | 9001493-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9001493m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |