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Cayman Myristoyl Ethanolamide; Purity- Greater Than Or Equal To 9
NETA PART: | CAYM-9001742-10 |
MFG.PART: | 9001742-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
Agmatine is a metabolite formed during polyamine biosynthesis with diverse biological activities. Agmatine is released from and taken up by synaptosomes, demonstrating neurotransmitter-like activity. It binds to human adrenergic receptors (ARs) and imidazoline (I) receptors (Kis = 46.98, 164.4, 26.3, and 74.4 μM for α2A-, α2B-, and α2c-ARs and I2b, respectively). Agmatine acts as an antagonist of the NMDA receptor (NMDAR) in a voltage- and concentration-dependent manner in primary rat hippocampal neurons and antagonizes nicotinic acetylcholine receptors (nAChRs) in intact chick retina at 1 mM., It is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 in mouse N1E-115 neuroblastoma cells (IC50 = 141 μM) and blocks ATP-sensitive potassium channels (KATP) in a concentration-dependent manner in mouse islets of Langerhans β-cells., Agmatine competitively inhibits neuronal, macrophage, endothelial, and inducible nitric oxide synthase (NOS; Kis = 660, 220, 7,500, and 260 μM, respectively) and irreversibly inactivates neuronal NOS in the presence of calmodulin (Ki = 29 μM). In vivo, agmatine (10 mg/kg) lowers the ED50 value by 5.2- and 4.7-fold for morphine (Item No. ) and [D-Pen2,D-Pen5]enkephalin (DPDPE), respectively, in mice in a tail flick assay. It increases the nephron filtration rate when microperfused into the urinary space of rats, an effect that is reversed by the non-selective NOS inhibitor L-NG-monomethyl arginine (L-NMMA; Item Nos. , ).
WARNING This product is not for human or veterinary use.
Technical Information
- NIH 11035
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
SKU | CAYM-9001742-10 |
---|---|
Supplier Part Number | 9001742-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9001742m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 142-58-5 |