We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Cayman Lignoceroyl Ethanolamide; Purity- Greater Than Or Equal To
NETA PART: | CAYM-9001744-10 |
MFG.PART: | 9001744-10 |
UNSPSC: | 12352200 |
Manufacturer: | Cayman |
Product Description
MK-0974 is an orally bioavailable antagonist of the calcitonin gene-related peptide (CGRP) receptor complex (Ki = 0.77 μM), which is composed of the calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1). MK-0974 binds selectively to the human CGRP receptor complex, over the adrenomedullin receptor complexes, which are composed of CRLR and RAMP2 or RAMP3 (Kis = >100 and 29 μM, respectively, in HEK293 cells). MK-0974 also binds to rhesus, canine, and rat CGRP receptor complexes (Kis = 1.2, 1,204, and 1,192 nM, respectively). MK-0974 inhibits cAMP accumulation stimulated by CGRP (Item No. ) with an IC50 value of 2.2 nM in HEK293 cells expressing the CGRP receptor complex. Ex vivo, MK-0974 (5 μM) reduces CGRP-induced vasodilation in isolated human meningeal arteries. MK-0974 also inhibits vasodilation induced by topical application of capsaicin (Item No. ) in rhesus monkeys (EC50 = 127 nM).
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: 10 mM
- Ethanol: 1 mg/ml
Shipping & Storage Information
SKU | CAYM-9001744-10 |
---|---|
Supplier Part Number | 9001744-10 |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cayman |
MSDS URL | https://www.caymanchem.com/msdss/9001744m.pdf |
Temperature | -20 |
Refrigerated-Frozen | Refrigerated |
CountryOfOrigin | US |
ProductLine | CAYM |
Qty | 10 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 2 Business Days |
Hazardous | N |
CAS Number | 10015-68-6 |